Weight Loss Drugs: Why 20% of Users May Not See Results
Weight Loss Drugs: Not a One-Size-Fits-All Solution
When Danielle Griffin gained easy access to weight loss drugs like Wegovy and Ozempic at minimal cost due to her insurance coverage, she had high hopes for significant weight loss. However, her experience with these medications left her disappointed, as the results fell short of her expectations.
Griffin’s story is not unique, as new research suggests that the effectiveness of obesity drugs can vary significantly among patients. While clinical trials have shown average weight loss ranging from 15% to 22% of body weight, real-world outcomes may differ. Studies indicate that 10% to 15% of participants in trials are nonresponders, with that number potentially rising to 20% in everyday use.
Dr. Fatima Cody Stanford, an obesity medicine specialist at Massachusetts General Hospital, emphasizes the role of genetics and hormones in weight regulation. “Each person’s response to these medications is unique,” she explains, highlighting the importance of managing patient expectations.
The effectiveness of GLP-1 receptor agonists, the class of drugs including Wegovy and Ozempic, depends on various factors. These include an individual’s genetic makeup, hormonal balance, and brain energy regulation. Additionally, pre-existing medical conditions and other medications can impact weight loss outcomes.
Dr. Katherine Saunders, an obesity medicine specialist at Weill Cornell Medicine, notes the emotional toll of unmet expectations. “Patients often feel discouraged when the drugs don’t work as anticipated,” she says, underscoring the need for comprehensive support in obesity treatment.
Identifying nonresponders early is crucial, according to Dr. Jody Dushay, an endocrinologist at Beth Israel Deaconess Medical Center. She suggests monitoring for early signs of drug effectiveness and being aware of side effects that may lead to discontinuation.
For those who don’t respond well to initial treatments, alternative approaches are available. These may include trying different drugs like Zepbound or implementing more comprehensive obesity treatment plans. Experts stress the importance of lifestyle changes in conjunction with medication for optimal weight management.
As the field of obesity treatment evolves, the emphasis remains on personalized treatment plans. Doctors play a crucial role in guiding patients through their weight loss journey, developing backup plans, and exploring alternative strategies for nonresponders.
This ongoing research into obesity treatments is supported by the AP Health and Science Department’s collaboration with the Howard Hughes Medical Institute’s Department of Science Education. The Associated Press maintains full responsibility for all content related to this topic.
